Quantification of impaired conscious awareness

fMRI signal changes in response to epileptiform EEG discharges during temporal lobe and absence seizures

We aim to develop an EEG-based bed-side test for the objective assessment of conscious awareness. Impaired conscious awareness has important practical consequences for people living with epilepsy. Recent pathophysiologic studies show that seizures with an impaired level of conscious awareness always affect widespread cortical networks and subcortical arousal systems. In light of these findings and their clinical significance, the International League Against Epilepsy (ILAE) has revised their classification system, which now includes awareness as one dimension in the classification of seizures (Fisher et al., 2017; Scheffer et al., 2017). However, as of yet, a bed side test for the objective assessment of conscious awareness does not exist. We aim to develop electroencephalography (EEG) as a measurement tool for conscious awareness.

Arbeitsgruppen der Neurologie an der Christian-Albrechts-Universität zu Kiel

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